PT-141
Bremelanotide
Acts on pathways in the brain involved in sexual desire. FDA approved as Vyleesi for certain women.
- Vial
- 10.0 mL
- Strength
- 2.0 mg/mL
- Typical dose
- 1.0 mg (50 units)
- Schedule
- As needed, no more than once in 24 hours
- Per vial
- About 20 doses
- FDA status
- FDA approved as Vyleesi for one specific use
What it is
PT-141 (bremelanotide) acts on melanocortin receptors in the brain, which play a role in sexual desire. It works on the brain rather than on blood flow, unlike medications such as sildenafil.
What the research shows
Bremelanotide was approved by the FDA in 2019 as Vyleesi to treat low sexual desire in premenopausal women. In clinical trials, the most common side effects were nausea, flushing, and headache, and it caused a short-lived rise in blood pressure.
How it's used
PT-141 is commonly supplied as a 10.0 mL vial at 2.0 mg/mL. A typical dose is 1.0 mg (50 units), injected under the skin, as needed, no more than once in 24 hours. Your prescriber sets your exact dose and schedule.
Common questions
When do I take it?
A
s
n
e
e
d
e
d
,
b
e
f
o
r
e
s
e
x
u
a
l
a
c
t
i
v
i
t
y
,
a
n
d
n
o
m
o
r
e
t
h
a
n
o
n
c
e
i
n
2
4
h
o
u
r
s
.
Y
o
u
r
p
r
e
s
c
r
i
b
e
r
w
i
l
l
t
e
l
l
y
o
u
h
o
w
f
a
r
a
h
e
a
d
t
o
t
a
k
e
i
t
.
Who shouldn't use it?
P
e
o
p
l
e
w
i
t
h
u
n
c
o
n
t
r
o
l
l
e
d
h
i
g
h
b
l
o
o
d
p
r
e
s
s
u
r
e
o
r
h
e
a
r
t
d
i
s
e
a
s
e
s
h
o
u
l
d
n
'
t
u
s
e
i
t
w
i
t
h
o
u
t
t
h
e
i
r
p
r
o
v
i
d
e
r
'
s
c
l
e
a
r
a
n
c
e
.
Is it safe?
E
v
e
r
y
p
e
p
t
i
d
e
h
a
s
p
o
s
s
i
b
l
e
s
i
d
e
e
f
f
e
c
t
s
,
a
n
d
m
a
n
y
h
a
v
e
l
i
m
i
t
e
d
l
o
n
g
-
t
e
r
m
r
e
s
e
a
r
c
h
i
n
p
e
o
p
l
e
.
Y
o
u
r
p
r
o
v
i
d
e
r
r
e
v
i
e
w
s
y
o
u
r
h
e
a
l
t
h
h
i
s
t
o
r
y
b
e
f
o
r
e
p
r
e
s
c
r
i
b
i
n
g
a
n
d
c
a
n
e
x
p
l
a
i
n
t
h
e
r
i
s
k
s
f
o
r
y
o
u
.
Good to know
- Available by prescription only, after an evaluation by a licensed provider.
- FDA approved only for the specific use above; other uses are off-label.
- See the side-effect guide for what to watch for.
