GLP Dosing Schedule
Weeks 1-4:
Dose: 2.5 mg weekly (16.7 units on a 1 mL syringe)
For Weeks 1–4, patients stay on a starter dose of 2.5 mg (16.7 units on a 1 mL syringe) once weekly. This phase helps the body adjust to the medication. Most people notice a reduced appetite, feeling full faster, and fewer cravings. Early side effects like mild nausea, bloating, or fatigue may occur but usually improve by Week 3 or 4. Eating slowly, drinking plenty of water, and avoiding heavy or greasy meals can make this period smoother.
Weeks 5-8:
Dose: 5.0 mg weekly (33.3 units on a 1 mL syringe)
For Weeks 5–8, patients increase to 5.0 mg (33.3 units on a 1 mL syringe) once weekly. This is the first therapeutic dose, where appetite control becomes stronger and weight-loss progress typically becomes more noticeable. Some mild side effects may return briefly—such as nausea, burping, or digestive changes—as the body adjusts to the higher dose. Most symptoms settle quickly. Eating smaller meals, staying hydrated, and avoiding high-fat foods will help keep this phase comfortable.
Weeks 9-12:
Dose: 7.0 mg weekly (50 units on a 1 mL syringe)
For Weeks 9–12, patients move to 7.0 mg (50 units on a 1 mL syringe) once weekly. This dose provides stronger therapeutic effects, with many patients experiencing steady, more predictable weight loss. Appetite and cravings typically decrease even further. Some mild side effects—like nausea, burping, or digestive slowdown—may briefly reappear as the dose increases but usually fade within a few days. Continuing to eat slowly, choose lighter meals, and stay hydrated helps keep this stage comfortable.
Week 13-16+:
Dose: 10 mg weekly (66.7 units on a 1 mL syringe)
For Weeks 13–16, patients advance to 10 mg (66.7 units on a 1 mL syringe) once weekly. This dose is typically where many people see their most consistent weight-loss momentum. Hunger cues and cravings often become significantly reduced, helping patients maintain smaller portions with ease. Mild side effects—such as nausea or digestive discomfort—may reappear briefly as the dose increases but usually settle quickly. Staying hydrated, eating smaller portions, and avoiding heavy meals can make this stage smoother.
Step-Up Therapy:
12.5 mg weekly (83.3 units) for added appetite and craving control
15 mg weekly (100 units) for maximum therapeutic support
Step-Up Therapy includes the highest doses for patients who need additional support beyond the standard schedule. The first option is 12.5 mg (83.3 units on a 1 mL syringe) once weekly, which provides stronger appetite suppression and more pronounced weight-loss effects. If further support is needed, patients may progress to 15 mg (100 units on a 1 mL syringe) once weekly, the maximum dose. At these levels, some patients may notice temporary digestive side effects when increasing, but they typically settle with hydration, light meals, and slow eating.